Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × EV Treg, vs 3 × EV Treg with IL2, vs 3 × 1G12t Treg, vs 3 × 3A10t Treg,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285527_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1204308 and SRA study SRP554418. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8703860 EV Treg, rep1 EV Treg,
- GSM8703861 EV Treg, rep2 EV Treg,
- GSM8703862 EV Treg, rep3 EV Treg,
- GSM8703863 EV Treg with IL2, rep1 EV Treg with IL2,
- GSM8703864 EV Treg with IL2, rep2 EV Treg with IL2,
- GSM8703865 EV Treg with IL2, rep3 EV Treg with IL2,
- GSM8703866 1G12t Treg, rep1 1G12t Treg,
- GSM8703867 1G12t Treg, rep2 1G12t Treg,
- GSM8703868 1G12t Treg, rep3 1G12t Treg,
- GSM8703869 3A10t Treg, rep1 3A10t Treg,
- GSM8703870 3A10t Treg, rep2 3A10t Treg,
- GSM8703871 3A10t Treg, rep3 3A10t Treg,
- GSE275780 Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy [RNA-seq] 17 samples shares regulatory, therapy
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares regulatory, therapy
- GSE268778 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [scRNA-seq] 20 samples shares regulatory, therapy
- GSE223651 Attenuated IL-2 Signaling Rewires Transcriptional and Metabolic Programs in T Cells to Enable Coupling Proliferation and Stemness 21 samples shares il-2
- GSE279898 Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation 12 samples shares il-2
- GSE262867 Pancreatic Beta-Cell IL-22 Receptor Deficiency Induces Age-Dependent Dysregulation of Insulin Biosynthesis and Systemic Glucose Homeostasis 10 samples shares il-2
- GSE342584 Tumor-targeted IL-10 combined with IL-2 amplifies anti-tumor immunity 3 samples shares il-2
- GSE250205 A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies 32 samples shares il-2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.