Enhancing TREM2 expression activates microglia and modestly mitigates Tau pathology and neurodegeneration
Single-cell RNA-seq · mouse · 24 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegenerationJournal of neuroinflammation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285713_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1205691 and SRA study SRP554939. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 24 more — browse all 24 samples with per-sample file links →
- GSE277167 Protective variant in PLCγ2 mitigates Alzheimer’s disease associated pathology via enhancing beneficial microglia functions 31 samples shares enhancing, microglia, mitigates, pathology
- GSE316055 Differential downstream signaling in microglia lacking Alzheimer’s-related TREM2 or its adaptor TYROBP/DAP12 72 samples shares trem2, microglia
- GSE324025 Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity. 59 samples shares trem2, microglia
- GSE291648 PLCG2 modulates TREM2 expression and signaling in response to Alzheimer’s disease pathology 24 samples shares trem2, pathology
- GSE271074 TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism 23 samples shares trem2, microglia
- GSE307686 The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer’s Disease by Impairing Microglial Function [scRNA-Seq] 15 samples shares trem2, microglia
- GSE293041 Single-cell transcriptome analysis of wildtype, TREM2 knockout, GPR34 knock-out or TREM2/GPR34 double knock-out primary microglia from wildtype and APP knock-in mice (8 months) 10 samples shares trem2, microglia
- GSE293219 Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. 36 samples shares enhancing, mitigates
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.