Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity.
Single-nucleus RNA-seq · mouse · 59 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 59 samples: 15 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticitybioRxiv : the preprint server for biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE324025_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1433024 and SRA study SRP681379. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 59 samples.
How we read this: 15 replicated groups read from 59 sample titles; they account for 59 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9566862 Saline_1 Saline
- GSM9566863 Saline_2 Saline
- GSM9566864 Saline_3 Saline
- GSM9566865 Saline_4 Saline
- GSM9566866 Saline_5 Saline
- GSM9566867 L-dopa_1 L-dopa
- GSM9566868 L-dopa_2 L-dopa
- GSM9566869 L-dopa_3 L-dopa
- GSM9566870 L-dopa_4 L-dopa
- GSM9566871 L-dopa_5 L-dopa
- GSM9566872 Saline_C_1 Saline_C
- GSM9566873 Saline_C_2 Saline_C
- GSM9566874 Saline_C_3 Saline_C
- GSM9566875 Saline_C_4 Saline_C
- GSM9566876 Saline_C_5 Saline_C
- GSM9566877 L-dopa_C_1 L-dopa_C
- GSM9566878 L-dopa_C_2 L-dopa_C
- GSM9566879 L-dopa_C_3 L-dopa_C
- GSM9566880 L-dopa_C_4 L-dopa_C
- GSM9566881 L-dopa_C_5 L-dopa_C
- GSM9566882 Saline_Ctrl_1 Saline_Ctrl
- GSM9566883 Saline_Ctrl_2 Saline_Ctrl
- GSM9566884 Saline_Ctrl_3 Saline_Ctrl
- GSM9566885 L-dopa_Ctrl_1 L-dopa_Ctrl
- GSM9566886 L-dopa_Ctrl_2 L-dopa_Ctrl
- GSM9566887 L-dopa_Ctrl_3 L-dopa_Ctrl
- GSM9566888 L-dopa_PLX_1 L-dopa_PLX
- GSM9566889 L-dopa_PLX_2 L-dopa_PLX
- GSM9566890 L-dopa_PLX_3 L-dopa_PLX
- GSM9566891 L-dopa_PLXrev_1 L-dopa_PLXrev
- GSM9566892 L-dopa_PLXrev_2 L-dopa_PLXrev
- GSM9566893 L-dopa_PLXrev_3 L-dopa_PLXrev
- GSM9566894 L-dopa_x1_Ctrl_1 L-dopa_x1_Ctrl
- GSM9566895 L-dopa_x1_Ctrl_2 L-dopa_x1_Ctrl
- GSM9566896 L-dopa_x1_Ctrl_3 L-dopa_x1_Ctrl
- GSM9566897 L_DOPA_GFP_1 L_DOPA_GFP
- GSM9566898 L_DOPA_GFP_2 L_DOPA_GFP
- GSM9566899 L_DOPA_GFP_3 L_DOPA_GFP
- GSM9566900 L_DOPA_GFP_4 L_DOPA_GFP
- GSM9566901 Saline_GFP_1 Saline_GFP
+ 19 more — browse all 59 samples with per-sample file links →
- GSE243110 A TrkB and TrkC partial agonist prevents synaptic plasticity deficits and elicits activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer’s disease mouse model 36 samples shares microglial, plasticity
- GSE327851 Transneuronal cytokine delivery promotes functional recovery across spinal cord contusion severities via descending circuit plasticity 9 samples shares plasticity, circuit
- GSE245651 BACH1 acts as a pioneer repressor to enable macrophage plasticity and adaptation across tissues and inflammatory contexts 165 samples shares plasticity, acts
- GSE327645 BACH1 acts as a pioneer repressor to enable macrophage plasticity and adaptation across tissues and inflammatory contexts [RNA-seq/ATAC-seq] 28 samples shares plasticity, acts
- GSE254229 ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice 141 samples shares microglial
- GSE266472 Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice 123 samples shares plasticity
- GSE327428 GPR34 regulation of disease-associated microglial states in mice 96 samples shares microglial
- GSE236201 Maternal Circadian Rhythms during Pregnancy Dictate Metabolic Plasticity in Offspring 96 samples shares plasticity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.