← BioTransfer GEO Dataset Finder
GEO series

snRNA-seq of the hippocampus of Mr1+/+ P301S mice and Mr1-/- P301S mice

GSE285822 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/26 Platform GPL24247
Summary
We performed snRNA-seq using 10xgenomics platform to study the role of MAIT cells in regulating neuroinflammation in mice with neurodegenerative tau pathology. MAIT cells are a type of innate-like T cells that are present in the meninges of mice carrying neurodgenerative human tau mutant transgene. This is the first study to examine single nucleus transcriptome profiles of human tau mice lacking MAIT cells.
Published in
MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice
Zhang Y, Yang Z, Jiang N et al. · Journal of neuroinflammation 2025 · PMID 40114233 · doi:10.1186/s12974-025-03413-7
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE285822_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1206150 and SRA study SRP555154. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.