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Activation of Piezo1 induces heterogeneity in LSK cells leading to HSC proliferation and myelopoiesis [scRNA-seq]

GSE285920 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/11/03 Platform GPL24247
Summary
Bone marrow haematopoietic stem cells (HSCs) are mobilised into blood under various stresses. Although they are exposed to shear stress during circulation, the role of mechanical stimulation in regulating HSCs remains unknown. Piezo1, a mechanosensory ion channel, was implicated in regulation of haematopoietic cells. We analysed the transcriptional heterogeneity of LSK cells from mice treated with the Piezo1 agonist Yoda1 for 2 weeks. Our study demonstrated that activation of Piezo1 promoted HSC proliferation and differentiation toward the myeloid lineage, as evidenced by an increase in HSC numbers and the upregulation of myeloid transcription factors.
Published in
Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging
Shang T, Zhao L, Ying S et al. · Nature aging 2026 · PMID 41482519 · doi:10.1038/s43587-025-01039-1
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Also filed as BioProject PRJNA1206980 and SRA study SRP555471. Searching any of these in the dataset finder brings you back here.

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