The Inflammaging Microenvironment Induces Dysfunctional Rewiring of Tfh Cell Differentiation
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 10 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiationJCI insight · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE286979_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1210625 and SRA study SRP557294. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 14 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8735681 BRI-1893_GEX_HTO_Library
- GSM8735682 BRI-1895_TCR_Library
- GSM8735683 BRI-1737_GEX_HTO_Library
- GSM8735684 BRI-1739_TCR_Library
- GSM8735685 BRI-2075_GEX_HTO_Library
- GSM8735686 BRI-2077_TCR_Library
- GSM8735687 BRI-2227_GEX_HTO_Library
- GSM8735688 BRI-2229_TCR_Library
- GSM8735689 Control_Tfh_bulk RNA-seq 1
- GSM8735690 Control_Tfh_bulk RNA-seq 2
- GSM8735691 Control_Tfh_bulk RNA-seq 3
- GSM8735692 Aging_Tfh_bulk RNA-seq 1
- GSM8735693 Aging_Tfh_bulk RNA-seq 2
- GSM8735694 Aging_Tfh_bulk RNA-seq 3
- GSE282726 FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment 25 samples shares microenvironment, induces
- GSE295662 Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival 16 samples shares microenvironment, rewiring
- GSE264696 Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional mechanisms [CITE-seq] 16 samples shares rewiring
- GSE66383 Disruptions of Topological Chromatin Domains Causes Pathogenic Rewiring of Gene-Enhancer Interactions 31 samples shares rewiring
- GSE181985 Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment 31 samples shares microenvironment
- GSE152277 G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT 30 samples shares microenvironment
- GSE251936 Circumventing Resistance within the Ewing Sarcoma Microenvironment by Anti-MCAM Chimeric Antigen Receptor Modified Ex-vivo Expanded Natural Killer Cells Combinatorial Therapy 22 samples shares microenvironment
- GSE312133 Intrinsic mechanisms and microenvironmental cues fine-tune plasticity of esophageal progenitors 26 samples shares microenvironment
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.