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Endothelial KLF15/VASN axis inhibits angiogenesis via activation of Notch1 signaling [ChIP-Seq]

GSE287265 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/05/24 Platform GPL24676
Summary
Kruppel like factors (KLFs) are a subfamily of zinc finger proteins. As one of the family members, KLF15 can specifically bind to GC rich sequences on the promoter, thereby exerting transcriptional regulatory effects. Here we found that KLF15 negatively regulates angiogenesis in endothelial cells. KLF15 induces an increase in vasorin (VASN) expression, thereby activating the Notch signaling pathway and leading to a decrease in angiogenesis. These findings point to an KLF15/VASN axis as critical determinants of Notch signaling activation.
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Also filed as BioProject PRJNA1211995 and SRA study SRP558020. Searching any of these in the dataset finder brings you back here.

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