Activation of M3 muscarinic ameliorates experimental autoimmune encephalomyelitis by restoring microglial quiescence
RNA-seq (gene expression) · mouse · 9 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 9 samples: 3 × BV2, Control, biol vs 3 × BV2, LPS, biol vs 3 × BV2, LPS+Pilo, biolGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298934_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1271957 and SRA study SRP589808. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 9 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9026217 BV2, Control, biol rep1 BV2, Control, biol
- GSM9026218 BV2, Control, biol rep2 BV2, Control, biol
- GSM9026219 BV2, Control, biol rep3 BV2, Control, biol
- GSM9026220 BV2, LPS, biol rep1 BV2, LPS, biol
- GSM9026221 BV2, LPS, biol rep2 BV2, LPS, biol
- GSM9026222 BV2, LPS, biol rep3 BV2, LPS, biol
- GSM9026223 BV2, LPS+Pilo, biol rep1 BV2, LPS+Pilo, biol
- GSM9026224 BV2, LPS+Pilo, biol rep2 BV2, LPS+Pilo, biol
- GSM9026225 BV2, LPS+Pilo, biol rep3 BV2, LPS+Pilo, biol
- GSE287323 Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in an experimental autoimmune encephalomyelitis (EAE) model of demyelination 19 samples shares encephalomyelitis, experimental, autoimmune
- GSE279351 Liver-specific inactivation of Cideb improves metabolic profiles and ameliorates steatohepatitis and fibrosis in animal models for MASH 45 samples shares ameliorates, activation
- GSE275510 Deciphering Motor Dysfunction and Microglial Activation in mThy1-α-Synuclein Mice: A Comprehensive Study of Behavioral, Gene Experssion, and Methylation Changes [RNA-Seq] 20 samples shares activation, microglial
- GSE284505 Chronic sleep deprivation promotes experimental autoimmune uveitis through STAT1 phosphorylation, ISG15 expression and enhanced pathogenicity of macrophages 12 samples shares experimental, autoimmune
- GSE250460 Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells 20 samples shares activation, quiescence
- GSE255212 Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interaction during Primordial Follicle Activation 762 samples shares activation
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares activation
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.