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Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via elevated intracellular calcium load

GSE287534 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/01/01 Platform GPL24247
Summary
Atherosclerosis is a leading cause of macrovascular complications in type 2 diabetes mellitus (T2DM). Lipid metabolism disorders in T2DM alter exosomal cargos, affecting vascular endothelial cells and impairing vascular endothelium-dependent relaxation. This study investigates the link between T2DM and atherosclerosis, focuing on adipose tissue-derived exosomes (AT-Exosomes) as key pathogenic factors in T2DM.
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Direct links to NCBI, no account and no request form: the whole study as GSE287534_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1213687 and SRA study SRP558660. Searching any of these in the dataset finder brings you back here.

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