TMEM106B deficiency leads to alterations in lipid metabolism and obesity in the TDP-43Q331K knock-in mouse model
RNA-seq (gene expression) · mouse · 37 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 37 samples: 8 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TMEM106B deficiency leads to alterations in lipid metabolism and obesity in the TDP-43(Q331K) knock-in mouse modelCommunications biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287573_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1213765 and SRA study SRP558731. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 37 samples.
How we read this: 8 replicated groups read from 37 sample titles; they account for 37 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8748201 Liver,WT1 Liver,WT
- GSM8748202 Liver,WT2 Liver,WT
- GSM8748203 Liver,WT3 Liver,WT
- GSM8748204 Liver,WT4 Liver,WT
- GSM8748205 Liver,Q331K1 Liver,Q331K
- GSM8748206 Liver,Q331K2 Liver,Q331K
- GSM8748207 Liver,Q331K3 Liver,Q331K
- GSM8748208 Liver,Q331K4 Liver,Q331K
- GSM8748209 Liver,BKO1 Liver,BKO
- GSM8748210 Liver,BKO2 Liver,BKO
- GSM8748211 Liver,BKO3 Liver,BKO
- GSM8748212 Liver,BKO4 Liver,BKO
- GSM8748213 Liver,BKOQ331K1 Liver,BKOQ331K
- GSM8748214 Liver,BKOQ331K2 Liver,BKOQ331K
- GSM8748215 Liver,BKOQ331K3 Liver,BKOQ331K
- GSM8748216 Liver,BKOQ331K4 Liver,BKOQ331K
- GSM8748217 Cortex,WT1 Cortex,WT
- GSM8748218 Cortex,WT2 Cortex,WT
- GSM8748219 Cortex,WT3 Cortex,WT
- GSM8748220 Cortex,WT4 Cortex,WT
- GSM8748221 Cortex,WT5 Cortex,WT
- GSM8748222 Cortex,Q331K1 Cortex,Q331K
- GSM8748223 Cortex,Q331K2 Cortex,Q331K
- GSM8748224 Cortex,Q331K3 Cortex,Q331K
- GSM8748225 Cortex,Q331K4 Cortex,Q331K
- GSM8748226 Cortex,Q331K5 Cortex,Q331K
- GSM8748227 Cortex,Q331K6 Cortex,Q331K
- GSM8748228 Cortex,BKO1 Cortex,BKO
- GSM8748229 Cortex,BKO2 Cortex,BKO
- GSM8748230 Cortex,BKO3 Cortex,BKO
- GSM8748231 Cortex,BKO4 Cortex,BKO
- GSM8748232 Cortex,BKO5 Cortex,BKO
- GSM8748233 Cortex,BKOQ331K1 Cortex,BKOQ331K
- GSM8748234 Cortex,BKOQ331K2 Cortex,BKOQ331K
- GSM8748235 Cortex,BKOQ331K3 Cortex,BKOQ331K
- GSM8748236 Cortex,BKOQ331K4 Cortex,BKOQ331K
- GSM8748237 Cortex,BKOQ331K5 Cortex,BKOQ331K
- GSE254704 Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice 32 samples shares deficiency, obesity
- GSE307255 HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice 32 samples shares alterations, lipid
- GSE280933 Custom-designed lipid-based nanoparticles efficiently deliver mRNA to reverse the pathogenesis of LAL deficiency in a preclinical model 28 samples shares deficiency, lipid
- GSE296499 CK2α deletion in the hematopoietic compartment leads to mild alterations in terminally differentiated cells and expansion of stem cells 22 samples shares alterations, leads
- GSE282601 Intestinal epithelial cell EphB4 deficiency on high fat diet-induced obesity 16 samples shares deficiency, obesity
- GSE296365 Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities 16 samples shares alterations, leads
- GSE237833 Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome 14 samples shares deficiency, obesity
- GSE304787 Therapeutic targeting of lipidated amino acid deficiency ameliorates MASH via a PPARα/CCL2 axis 14 samples shares deficiency, lipid
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.