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Transcriptome profiling of Actr3 KO mIMCD3 cells

GSE287610 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/10/16 Platform GPL24247
Summary
Actr3 WT (control) and Actr3 KO mIMCD3 cells were generated using CRISPR/Cas9 and independent gRNAs for control and KO cell lines. Single cells clones (Ctrl.-1, Crtl.-2, KO-1, KO-2) were selected and validated by western blotting confirming loss of Actr3 in KO cell lines on protein level. Transcriptome profiling (RNA-Sequencing) and differential gene expression analysis of independent replicates per cell line was performed.
Published in
Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease
Rogg M, Weißer L, Maier JI et al. · Science advances 2025 · PMID 41313769 · doi:10.1126/sciadv.ady1623
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Also filed as BioProject PRJNA1213816 and SRA study SRP558797. Searching any of these in the dataset finder brings you back here.

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