GEO series
Role of IL10 signaling in the circadian control of host response to Influenza infection
GSE287759
Mus musculus
Expression profiling by high throughput sequencing
20 samples
2025/01/29
GPL24247
Summary
The circadian clock confers a time-of-day specific protection against influenza A Virus (IAV) infection by regulating the host response and limiting immunopathology. IL10 is a cytokine with significant immunoregulatory functions; however, the role of IL10 in IAV is unclear, with reports of both benefit and harm from its blockade early during the infection. Since the expression of IL10R shows diurnal rhythmicity in the lungs, we tested if IL10 signaling contributes to time-of-day specific protection against IAV.
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Paper (PMID 41274514) ↗
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