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Effect of encapsulating peritoneal sclerosis modeling on mice peritoneums

GSE288014 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/27 Platform GPL24247
Summary
Encapsulating peritoneal sclerosis (EPS) is a life-threatening fibrotic condition characterized by severe abdominal adhesions, chronic inflammation, and significant morbidity. The lack of effective treatments for EPS stems from a limited understanding of its underlying mechanisms. Previous EPS models relied on intraperitoneal injection of surgical hygiene solution (SHS), requiring 8 weeks to establish. Here, we modified the model by integrating both PD and lipopolysaccharide (LPS), leading to the formation of stable adhesions in just 3 weeks.This model better simulates the pathophysiological progression of EPS by reflecting more clinically relevant risk factors, such as PD and peritonitis, and captures key features like inflammatory infiltration and extracellular matrix (ECM) deposition.
Published in
Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis
Sun J, Sun Y, Guo D et al. · Communications biology 2025 · PMID 40847090 · doi:10.1038/s42003-025-08662-z
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Also filed as BioProject PRJNA1215453 and SRA study SRP559779. Searching any of these in the dataset finder brings you back here.

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