GEO series
Neuronal GDF-15 delivery alters peripheral CD4+ T cell phenotype
GSE288193
Mus musculus
Expression profiling by high throughput sequencing
20 samples
2025/11/20
GPL24247
Summary
In this study we investigated the immunomodulatory properties of GDF-15 in the context of neuroinflammation. We exploited neuronal gene therapy to overexpress GDF-15 within the central nervous system, which protected mice from developing any clinical signs of neuroinflammation in the experimental autoimmune encephalitis (EAE) model. We discovered that GDF-15 delivery modulated the peripheral T cell response and prevented immune cells from transmigrating into the central nervous system.
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Paper (PMID 41540266) ↗
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