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Colonic epithelial and immune cells from young and aged mice

GSE288290 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2026/05/15 Platform GPL24247
Summary
Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are linked and influence regenerative capacity remains unclear. Here, we undertake a comprehensive assessment of age-related changes in the mouse small and large intestines at single-cell resolution.
Published in
Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal-Like Epithelial State
Korcari A, Tauc H, Duggan J et al. · Aging cell 2026 · PMID 42007500 · doi:10.1111/acel.70495
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Also filed as BioProject PRJNA1216786 and SRA study SRP560519. Searching any of these in the dataset finder brings you back here.

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