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Deletion of endothelial glycocalyx component endomucin impairs retinal vascularization and suppresses pathological neovascularization

GSE288833 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/15 Platform GPL34290
Summary
Endomucin (EMCN), an endothelial-selective glycocalyx component highly expressed in capillaries and venous endothelium, plays a critical role in regulating vascular endothelial growth factor receptor 2 (VEGFR2) endocytosis and downstream of VEGF signaling. Using a global EMCN knockout mouse model, we investigated the effects of EMCN deficiency on retinal vascularization during development and pathological angiogenesis. While Emcn-/- mice showed no significant difference in the avascular area in an oxygen-induced retinopathy (OIR) model, there was a significant reduction in neovascular tufts at postnatal day 17. RNA seq of the OIR retinas with gene ontology enrichment analysis indicate response to hypoxia and angiogenesis pathways were differentially regulated in Emcn-/- mice in OIR.
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Also filed as BioProject PRJNA1219573 and SRA study SRP561845. Searching any of these in the dataset finder brings you back here.

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