← BioTransfer GEO Dataset Finder
GEO series

Single-cell RNA sequencing profiling of periarticular tissue from epidermal-specific SPRY1-deficient (Spry1 cKO) mice and control mice

GSE289142 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/27 Platform GPL21273
Summary
Spry1 cKO mice were found spontaneously developed psoriasis-like skin inflammation and arthritis.To further investigate the periarticular immune microenvironment in paws, single-cell RNA sequencing of the periarticular tissue from Spry1 cKO and control mice was performed.
Published in
CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling
Xu F, Cui YZ, Yang XY et al. · The Journal of clinical investigation 2025 · PMID 40471688 · doi:10.1172/JCI186135
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE289142_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1221796 and SRA study SRP562891. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.