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Autocrine ECM molecules establish MSC quiescence during incisor development by disrupting WNT ligand trafficking process

GSE289364 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/09/11 Platform GPL24247
Summary
We used single-cell sequencing to understand the development of incisor tissues from mice. We utilized the single-cell sequencing platform from SeekGene Biotechnology to study the heterogeneity of mesenchyme in incisors at both embryonic and adult stages of mice, and discovered that Smoc2 is a marker gene for mesenchymal stem cells in mouse incisors. We employed the 10X platform to sequence the incisor tissues of smoc1/2 knockout (ko) and control mice during the embryonic stage to investigate the molecular mechanisms underlying the developmental abnormalities in smoc1/2 ko mice.Our study provides a molecular mechanism explaining how stem cells form during development.
Published in
Autocrine ECM molecules establish MSC quiescence during incisor development by disrupting WNT ligand trafficking process
Chen Z, Cai M, Wang Y et al. · Nature communications 2025 · PMID 41309624 · doi:10.1038/s41467-025-65705-z
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Also filed as BioProject PRJNA1222787 and SRA study SRP563425. Searching any of these in the dataset finder brings you back here.

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