Branched Chain Amino Acids (BCAA) Modulate Metabolic Inflammation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 18 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Branched chain amino acids prime metabolic inflammationMolecular metabolism · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE289444_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1222928 and SRA study SRP563520. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8791603 BCAA_PBS_17_IgG
- GSM8791604 PBS_PBS_21_IgG
- GSM8791605 PBS_PBS_23_IgG
- GSM8791606 BCAA_PBS_24_IgG
- GSM8791607 PBS_PBS_45_IgG
- GSM8791608 PBS_PBS_46_IgG
- GSM8791609 BCAA_PBS_17_input
- GSM8791610 PBS_PBS_21_input
- GSM8791611 PBS_PBS_23_input
- GSM8791612 BCAA_PBS_24_input
- GSM8791613 PBS_PBS_45_input
- GSM8791614 PBS_PBS_46_input
- GSM8791615 BCAA_PBS_17_H3K27Ac
- GSM8791616 PBS_PBS_21_H3K27Ac
- GSM8791617 PBS_PBS_23_H3K27Ac
- GSM8791618 BCAA_PBS_24_H3K27Ac
- GSM8791619 PBS_PBS_45_H3K27Ac
- GSM8791620 PBS_PBS_46_H3K27Ac
- GSE295425 Targeting branched-chain amino acids alleviates pulmonary fibrosis [CUT&Tag, histone_modification] 20 samples shares branched, chain, amino, acids
- GSE295426 Targeting branched-chain amino acids alleviates pulmonary fibrosis [RNA-seq] 54 samples shares branched, chain, amino, acids
- GSE186649 A mitochondrial long-chain fatty acid oxidation defect in a mouse leads to dysregulation of plasma long-chain acylcarnitines, dysregulation of plasma amino acids, and an increased reliance on glucocorticoid signaling to maintain euglycemia during fasting 50 samples shares chain, amino, acids
- GSE291652 Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation 18 samples shares branched, chain, amino
- GSE268260 Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy 10 samples shares branched, chain, amino
- GSE281510 Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy 24 samples shares chain, acids
- GSE289295 Heme Biosynthesis Regulates BCAA Catabolism and Thermogenesis in Brown Adipose Tissue 60 samples shares bcaa
- GSE295376 Conserved Noncoding Cis-Elements Associated with Hibernation Modulate Metabolic and Behavioral Adaptations in Mice 86 samples shares modulate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.