Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy
Single-nucleus RNA-seq · mouse · 24 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophyiScience · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281510_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1183858. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 24 more — browse all 24 samples with per-sample file links →
- GSE267771 KMT2C Deficiency Drives Luminal Transdifferentiation into Double-Negative Prostate Cancer and Sensitizes to Fatty Acid Synthase Inhibition [RNA-Seq] 22 samples shares inhibition, fatty
- GSE309904 Acute kidney injury following fatty liver ischemia-reperfusion injury: indirect protection by hepatic ferroptosis inhibition 12 samples shares inhibition, fatty
- GSE318028 Pharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficits 246 samples shares inhibition
- GSE293819 Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance 142 samples shares inhibition
- GSE307181 Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor 96 samples shares inhibition
- GSE303258 Mouse placentae generated by in vitro fertilization exhibit altered gene expression, activated hypoxia responses and reduced fitness. 96 samples shares reduced
- GSE235623 MERTK inhibition for the treatment of tissue fibrosis [RNA-seq] 86 samples shares inhibition
- GSE278534 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization 76 samples shares inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.