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Activity-dependent development of the body's touch receptors

GSE289450 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/02/12 Platform GPL21626
Summary
We report a role for activity in the development of the primary sensory neurons that detect touch. Genetic deletion of Piezo2, the principal mechanosensitive ion channel in somatosensory neurons, caused profound changes in the formation of mechanosensory end organ structures. Peripheral nervous system specific deletion of the voltage-gated sodium channel Nav1.6 (Scn8a), which resulted in altered electrophysiological responses to mechanical stimuli, also disrupted somatosensory neuron morphologies, supporting a role for neuronal activity in end organ formation. Single cell RNA sequencing of Piezo2 mutants revealed changes in gene expression in the sensory neurons activated by light mechanical forces, whereas other neuronal classes were minimally affected, and genetic deletion of Piezo2-dependent genes partially reproduced the defects in mechanosensory neuron structures observed in Piezo2 mutants. These findings indicate that mechanically evoked neuronal activity acts early in life to shape the maturation of mechanosensory end organs that underlie our sense of gentle touch.
Published in
Activity-dependent development of the body's touch receptors
Santiago C, Siegrist J, Africawala N et al. · Neuron 2025 · PMID 40381613 · doi:10.1016/j.neuron.2025.04.015
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Also filed as BioProject PRJNA1222969 and SRA study SRP563523. Searching any of these in the dataset finder brings you back here.

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