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Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility [snRNA-seq]

GSE289589 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/02/03 Platform GPL34290
Summary
The native microbiome influences a plethora of host processes, including neurological function. However, its impacts on diverse brain cell types remains poorly understood. Here, we performed single nucleus RNA sequencing on hippocampi from wildtype, germ-free mice and reveal the microbiome-dependent transcriptional landscape across all major neural cell types. We found conserved impacts on key adaptive immune and neurodegenerative transcriptional pathways, underscoring the microbiome’s contributions to disease-relevant processes. In addition, mono-colonization with Escherichia coli was found to induce a distinct adaptive immune and neurogenerative disease-associated cell state, suggesting increased disease susceptibility.
Published in
Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility
Blackmer-Raynolds L, Lipson LD, Kozlov A et al. · Cell systems 2026 · PMID 41638211 · doi:10.1016/j.cels.2025.101481
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Also filed as BioProject PRJNA1223798 and SRA study SRP564073. Searching any of these in the dataset finder brings you back here.

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