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scRNA and TCR-Seq of peripheral blood mononuclear cells (PBMC) from r/r classical Hodgkin Lymphoma patients under anti-PD1 therapy.

GSE290026 Homo sapiens (human) Single-cell RNA-seq 23 samples Submitted 2025/02/24 Platform GPL18573
At a glance

Single-cell RNA-seq · human · 23 samples

What it is
Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
Organism
Homo sapiens (human)
Topic
Hodgkin lymphomaThis series is part of our curated briefing on it.
Samples
23 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
The immune cell dynamics in the peripheral blood of cHL patients receiving anti-PD1 treatmentFrontiers in oncology · 2025
Summary (written by the submitters)
We did scRNA and TCR-seq in order to determine the immunophenotic profile of refractory and relapsed patients under anti-PD1 therapy and evaluate based on their response.
Published in
The immune cell dynamics in the peripheral blood of cHL patients receiving anti-PD1 treatment
Cristaldi V, Terzi di Bergamo L, Patruno L et al. · Frontiers in oncology 2025 · PMID 40182035 · doi:10.3389/fonc.2025.1518107
This dataset
Open GSE290026 in finder → Find more human RNA-seq datasets → Hodgkin lymphoma landscape →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290026_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.

Also filed as BioProject PRJNA1225759 and SRA study SRP565085. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40182035) ↗
Study design
6 conditions, mostly with about 4 replicates each
PD_BASELINE_Patient ×4 PD_POST_Patient ×4 CR_BASELINE_Patient ×4 CR_POST_Patient ×4 CR_INTERMEDIATE_Patient ×4 PD_INTERMEDIATE_Patient ×3

Supports a between-group comparison across 23 samples.

How we read this: 6 replicated groups read from 23 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
More Hodgkin lymphoma datasets

Search all human RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.