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FAM49B suppresses ovarian cancer cell growth through regulating MAPK signaling

GSE290202 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/02 Platform GPL24676
Summary
The family with sequence similarity 49 member B (FAM49B, also known as CYRI-B) has recently attracted interest as a new player in cancer development. Upregulation of FAM49B expression has been observed in ovarian cancer tissues. Here we show that knockdown of FAM49B significantly increased ovarian cancer growth the in vitro, ovo and xenograft model. Transcriptomic analysis of FAM49B-depleted and control cells revealed that the MAPK pathway was upregulated upon FAM49B silencing. Supporting the transcription analysis, we found that knockdown of FAM49B enhanced the activation of EGFR and downstream MEK-ERK signaling, whereas FAM49B overexpression exhibited opposite trends. Overall, our data show that FAM49B acts as a suppressor of cancer cell growth in ovarian cancer through regulating MAPK signaling.
Published in
FAM49B suppresses ovarian cancer cell growth through regulating MAPK signaling
Yue C, Zhou D, Zhou Y et al. · American journal of cancer research 2025 · PMID 41113986 · doi:10.62347/LVDV6967
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Also filed as BioProject PRJNA1226556 and SRA study SRP565593. Searching any of these in the dataset finder brings you back here.

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