Transcriptome of rNLS8 mice and controls injected with non-targeting control ASO
RNA-seq (gene expression) · mouse · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 21 samples: 21 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 miceNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE290262_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1226927 and SRA study SRP565653. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 21 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8809437 T_70267_TG
- GSM8809438 T_70252_TG
- GSM8809439 T_70264_WT
- GSM8809440 T_69532_WT
- GSM8809441 T_70262_WT
- GSM8809442 T_70263_TG
- GSM8809443 T_70256_WT
- GSM8809444 T_69527_WT
- GSM8809445 T_70260_WT
- GSM8809446 T_69526_TG
- GSM8809447 T_69531_TG
- GSM8809448 T_70261_TG
- GSM8809449 T_69523_WT
- GSM8809450 T_69524_TG
- GSM8809451 T60303_TG
- GSM8809452 T61334_WT
- GSM8809453 T61345_WT
- GSM8809454 T61333_WT
- GSM8809455 T61331_WT
- GSM8809456 T61340_TG
- GSM8809457 T61342_TG
- GSE274312 A cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation 24 samples shares aso, controls, control
- GSE288215 Alveolar macrophages critically control infection by seasonal human coronavirus OC43 to avoid severe pneumonia 12 samples shares aso, control
- GSE272206 Natural genetic variation in wild-derived mice controls host survival and transcriptional responses during endotoxic shock 24 samples shares controls, control
- GSE310620 RNA-seq in aortic smooth muscle cells from a mice lacking Arg1 expression in erytrhrocytes (RBC.ARG1-KO) and their litter mate controls (RBC.ARG1-WT) after culture in standard DMEM or foam cell medium (DIAM) 16 samples shares controls, control
- GSE255329 The retrotransposable element-silencing factor Daxx controls microglia identity and function in the adult brain 93 samples shares controls, control
- GSE305266 The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing 90 samples shares controls, control
- GSE288210 Comparative gene expression profiling of RNA-seq data from islets of β-cell-specific ZZEF1 knockout mice (βZKO-Mip) and their littermate controls, treated with either azoramide or DMSO. 11 samples shares controls, control
- GSE244066 Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain Type-2 immunity [RNA-seq: dissected tissues] 78 samples shares controls, control
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.