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Transcriptional differences between effector cells derived from freshly isolated and long-lived naïve P14 CD8 T cells on day 5 post-infection.

GSE290460 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/14 Platform GPL24247
Summary
The heterogeneity of antigen-specific naïve CD8 T cells has not yet been fully elucidated. We found that long-lived naïve CD8 T cells, incubated in naïve B6 mice for more than 30 days, generate significantly higher numbers of effector and memory CD8 T cells after lymphocytic choriomeningitis virus (LCMV)-Armstrong infection compared to freshly isolated naive CD8 T cells. To examine the mechanism of why long-lived naive CD8 T cells exhibit superior responses to infection, we compared transcriptional profiles between effector CD8 T cells derived from long-lived and freshly isolated naive CD8 T cells.
Published in
Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses
Sajiki Y, Ando S, Perkins CM et al. · bioRxiv : the preprint server for biology 2025 · PMID 41279312 · doi:10.1101/2025.10.16.682909
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Also filed as BioProject PRJNA1228117 and SRA study SRP566248. Searching any of these in the dataset finder brings you back here.

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