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Single-cell RNA-seq analysis of PDX (Patient-Derived Xenograft) tumors isolated from mouse spleens, treated with Empty CAR, anti-CD72 H24 nanoCAR or anti-CD72 NbD4.13 nanoCAR.

GSE290685 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/02/23 Platform GPL34328
Summary
Single-cell RNA-seq analysis was performed on human mantle cell lymphoma PDX (Patient-Derived Xenograft) tumors isolated from mouse spleens to examine gene expression changes after treatment of Empty CAR, humanized anti-CD72 nanobody-based CAR-T (“H24 nanoCAR”) or NbD4.13-based anti-CD72 nanoCAR-T.
Published in
Affinity-matured CD72-targeting nanobody CAR T cells enhance elimination of antigen-low B-cell malignancies
Izgutdina A, Rashid T, Temple WC et al. · Journal for immunotherapy of cancer 2025 · PMID 41469141 · doi:10.1136/jitc-2025-012013
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Direct links to NCBI, no account and no request form: the whole study as GSE290685_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1229542 and SRA study SRP566828. Searching any of these in the dataset finder brings you back here.

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