GEO series

Intestinal region-specific functions of AHR in intrinsic enteric neurons during infections

GSE290795 Mus musculus Expression profiling by high throughput sequencing; Other 8 samples Submitted 2025/08/19 Platform GPL24247

Summary

Intrinsic enteric neurons (iENs) form a crucial neuronal network within the myenteric and submucosal plexus of the gastrointestinal tract, primarily responsible for regulating gut peristalsis. The mechanisms by which iENs sense and integrate dietary and microbial signals to regulate intestinal homeostasis and inflammation remain unclear. Here we showed that environmental sensor aryl hydrocarbon receptor (AHR) was expressed in different iEN subsets in the ileum and colon, and AHR ligands differentially modulated iEN activity in these regions. Genetic perturbation of Ahr in neurons increased iEN activation in the ileum but conversely decreased it in the colon in response to different intestinal pathogens. Furthermore, neuronal AHR deficiency enhanced the clearance of bacterial pathogens, which was associated with increased proliferation and abundance of group 3 innate lymphoid cells in the ileum. Together, our findings demonstrate the region-specific functions of AHR in neurons in response to infections.

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Also filed as BioProject PRJNA1230130 and SRA study SRP567178. Searching any of these in the dataset finder brings you back here.

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