Single cell mRNA sequencing on esophageal cells of Krt5-CreERT2:R26SmoM2/EYFP (K5:Smo) mice untreated and treated with ibuprofen
Single-cell RNA-seq · mouse · 2 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Mus musculus (mouse)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Intrinsic mechanisms and microenvironmental cues fine-tune plasticity of esophageal progenitorsNature communications · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291090_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1231534 and SRA study SRP571074. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE291095 mRNA sequencing on esophageal cells of Krt5-CreERT2:R26SmoM2/EYFP (K5:Smo) mice, untreated and treated with ibuprofen 6 samples shares r26smom2, eyfp, krt5-creert2, esophageal, untreated, ibuprofen, treated, mrna
- GSE311819 Single cell mRNA sequencing on esophageal cells of WT and Krt5-CreERT2:R26SmoM2/EYFP (K5:Smo) mice 5 days after Tamoxifen administration 2 samples shares r26smom2, eyfp, krt5-creert2, esophageal, mrna
- GSE291094 mRNA sequencing on esophageal organoids derived from wild-type mice 8 samples shares esophageal, mrna
- GSE294847 mRNA sequencing on esophageal organoids derived from K5:Smo mice 5 days after tamoxifen injection. 6 samples shares esophageal, mrna
- GSE270219 Intraesophageally challenge of OVA to epicutaneously sensitized mice with loss of epithelial Ikkβ results in experimental EoE that is faithful to human EoE esophageal mucosal pathology. [I] 24 samples shares esophageal
- GSE333534 Targeting KRAS in a TRP53/KRAS mouse and organoid model inhibits Barrett Esophagus to Gastroesophageal Adenocarcinoma progression 20 samples shares esophageal
- GSE294269 The Role of Epithelial IKKβ in the Transition from Normal to Precancerous Tissue in Esophageal Epithelium 16 samples shares esophageal
- GSE242438 Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy [RNAseq_Eso] 6 samples shares esophageal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.