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Elevated EGR1 Binding at Enhancers in Excitatory Neurons Correlates with Neuronal Subtype-Specific Epigenetic Regulation

GSE291158 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/21 Platform GPL24247
Summary
In this study, we generated epigenetic maps profiles to perform comparative histone modification analysis between excitatory and inhibitory neurons. We found that neuronal cell-type specific histone modifications are enriched in super enhancer regions containing abundant EGR1 motifs. Further CUT&RUN data validated that more EGR1 binding sites can be detected in excitatory neurons and primarily located in enhancers. RNA-seq data generated from FACS-sorted excitatory and inhibitory nuclei provided additional evidence supporting the neuronal subtype-specific regulatory function of EGR1.
Published in
Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulation
Yin L, Xu X, Conacher B et al. · BMC biology 2025 · PMID 40784942 · doi:10.1186/s12915-025-02357-x
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Also filed as BioProject PRJNA1232114 and SRA study SRP568100. Searching any of these in the dataset finder brings you back here.

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