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The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors [DNase-seq]

GSE291319 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2025/10/30 Platform GPL21493
Summary
Helper innate lymphoid cells (ILC) play important functions in immunity and tissue homeostasis, but their development remains poorly understood. In this study, we identified NFIL3 as the earliest known requirement during ILC development. Forced expression of NFIL3 in mouse lymphoid progenitors in vitro triggered the staged expression of downstream transcription factors including Tcf7, Gata3, Zbtb16 and Id2 that are implicated in ILC development. Thus, NFIL3 resides at the apex of a hierarchy of transcription factors important for innate lymphocyte development, and is necessary and sufficient to impose the innate lymphoid cell fate.
Published in
The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors
Léger J, Artano E, Coulais D et al. · Immunity 2025 · PMID 41172988 · doi:10.1016/j.immuni.2025.10.005
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Also filed as BioProject PRJNA1232816 and SRA study SRP568527. Searching any of these in the dataset finder brings you back here.

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