← BioTransfer GEO Dataset Finder
GEO series

DMSO-induced human embryo model reveals V-ATPase requirement in cavitation

GSE291369 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2026/03/12 Platform GPL24676
Summary
This study focuses on the key regulatory mechanisms of lysosomal acidification in early human embryonic development. By employing single-cell RNA sequencing technology (Smart-seq2), we conducted a systematic analysis of human morulae derived from three pronuclei, embryos arrested in development after treatment with 1 nM Concanamycin A, and control blastocysts. Through sequence alignment and quantitative analysis based on the human reference genome, the study successfully revealed the significant biological role of lysosomal acidification in the differentiation process of the trophectoderm (TE). This finding provides a new theoretical perspective for a deeper understanding of the molecular mechanisms underlying embryonic developmental arrest.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE291369_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1231797 and SRA study SRP568363. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 7 more — browse all 7 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.