A reversible broad-spectrum antiviral targets the human V-ATPase VO domain
RNA-seq (gene expression) · human · 48 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 48 samples: 48 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infectionEmerging microbes & infections · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE313871_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1381702 and SRA study SRP655348. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 48 sample titles: 48 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9376940 Calu3, biological replicate 1, CA, 3 h
- GSM9376941 Calu3, biological replicate 3, CA, 3 h
- GSM9376942 Calu3, biological replicate 2, CD, 3 h
- GSM9376943 Calu3, biological replicate 1, BAFA, 3 h
- GSM9376944 Calu3, biological replicate 3, BAFA, 3 h
- GSM9376945 Calu3, biological replicate 2, DMSO, 3 h
- GSM9376946 Calu3, biological replicate 1, CA, 6 h
- GSM9376947 Calu3, biological replicate 3, CA, 6 h
- GSM9376948 Calu3, biological replicate 2, CD, 6 h
- GSM9376949 Calu3, biological replicate 1, BAFA, 6 h
- GSM9376950 Calu3, biological replicate 3, BAFA, 6 h
- GSM9376951 Calu3, biological replicate 2, DMSO, 6 h
- GSM9376952 Calu3, biological replicate 1, CA, 12 h
- GSM9376953 Calu3, biological replicate 3, CA, 12 h
- GSM9376954 Calu3, biological replicate 2, CD, 12 h
- GSM9376955 Calu3, biological replicate 1, BAFA, 12 h
- GSM9376956 Calu3, biological replicate 3, BAFA, 12 h
- GSM9376957 Calu3, biological replicate 2, DMSO, 12 h
- GSM9376958 Calu3, biological replicate 1, CA, 24 h
- GSM9376959 Calu3, biological replicate 3, CA, 24 h
- GSM9376960 Calu3, biological replicate 2, CD, 24 h
- GSM9376961 Calu3, biological replicate 1, BAFA, 24 h
- GSM9376962 Calu3, biological replicate 3, BAFA, 24 h
- GSM9376963 Calu3, biological replicate 2, DMSO, 24 h
- GSM9376964 Calu3, biological replicate 2, CA, 3 h
- GSM9376965 Calu3, biological replicate 1, CD, 3 h
- GSM9376966 Calu3, biological replicate 3, CD, 3 h
- GSM9376967 Calu3, biological replicate 2, BAFA, 3 h
- GSM9376968 Calu3, biological replicate 1, DMSO, 3 h
- GSM9376969 Calu3, biological replicate 3, DMSO, 3 h
- GSM9376970 Calu3, biological replicate 2, CA, 6 h
- GSM9376971 Calu3, biological replicate 1, CD, 6 h
- GSM9376972 Calu3, biological replicate 3, CD, 6 h
- GSM9376973 Calu3, biological replicate 2, BAFA, 6 h
- GSM9376974 Calu3, biological replicate 1, DMSO, 6 h
- GSM9376975 Calu3, biological replicate 3, DMSO, 6 h
- GSM9376976 Calu3, biological replicate 2, CA, 12 h
- GSM9376977 Calu3, biological replicate 1, CD, 12 h
- GSM9376978 Calu3, biological replicate 3, CD, 12 h
- GSM9376979 Calu3, biological replicate 2, BAFA, 12 h
+ 8 more — browse all 48 samples with per-sample file links →
- GSE220574 HIV-1 Vpr targets PU.1 to vastly alter the antiviral machinery of HIV infected primary human macrophages 9 samples shares antiviral, targets
- GSE301682 An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo 12 samples shares broad-spectrum, antiviral
- GSE108445 A Reproducibility-Based Computational Framework Identifies An Inducible, Enhanced Antiviral Dendritic Cell State In HIV-1 Elite Controllers 420 samples shares antiviral
- GSE248828 High TSLP responses in the human infant airways are associated with pre-activated airway epithelial IFN antiviral immunity 47 samples shares antiviral
- GSE335881 Reversible epiblast regionalisation determines differentiation potential of human PSCs [RNA-Seq] 43 samples shares reversible
- GSE306280 Yellow fever vaccine propagation in primary human hepatocytes triggers antiviral and cytolytic responses 36 samples shares antiviral
- GSE316780 Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery 32 samples shares antiviral
- GSE237669 A single small molecule-based human embryo model reveals V-ATPase requirement in mammalian blastocyst cavitation 18 samples shares v-atpase
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.