← BioTransfer GEO Dataset Finder
GEO series

Selective inhibition of matrix mechanosensing in stromal cells attenuates cardiovascular fibrosis

GSE291370 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/03/08 Platform GPL20301Platform GPL24247
Summary
Matrix-derived biophysical cues are known to regulate the activation of fibroblasts and their subsequent transdifferentiation into myofibroblasts, but whether modulation of these signals can suppress fibrosis in intact tissues remains unclear, particularly in the cardiovascular system. We have employed single-cell/nucleus RNA sequencing of myofibroblasts differentiated from induced pluripotent stem cell-derived cardiac fibroblasts (iPSC-CFs), as well as mouse transverse aortic constriction (TAC) hearts to investigate whether modulation of matrix mechanosensing, in concert with TGF-beta inhibition, can potentiate the de-activation of fibrosis-promoting cardiac stromal populations in vitro and in vivo.
Published in
Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis
Cho S, Rhee S, Madl CM et al. · Nature 2025 · PMID 40307543 · doi:10.1038/s41586-025-08945-9
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE291370_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1233258 and SRA study SRP568695. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.