← BioTransfer GEO Dataset Finder
GEO series

Genome-wide binding profiles of Sp8 in differentiation mouse embryonic stem cells

GSE291742 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/11/12 Platform GPL11002
Summary
We have determined the genome-wide binding profile of the transcription factor Sp8. We found that Flag-Sp8 prefentially bound to promoters associatd with several growth factor signalling pathways, but most prominently with the Wnt/beta-catenin pathway to selectively promote mesoderm differentiation over neural. These data implicate Sp8 as new regulator of Wnt/beta-catenin target expression to promotes ES cell differentation into the mesoderm lineage.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE291742_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1235175 and SRA study SRP569870. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.