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Single-Cell Transcriptomics Highlights Macrophage-Driven Regulation of EndMT and Repair in Injured Muscle

GSE291782 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/21 Platform GPL24247
Summary
This study investigates the interactions between innate immune cells and vascular-associated cells within the regenerating muscle niche. Specifically, the transcriptomes of Cdh5-CreERT2:R26R-tdTomato mice were analysed following the partial ablation of infiltrating macrophages (MPs) to understand their influence on endothelial cell (EC) behaviour after injury. This work provides a comprehensive transcriptomic signature of the regenerative muscle niche and highlights key molecular interactions between MPs and ECs.
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Direct links to NCBI, no account and no request form: the whole study as GSE291782_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1235237 and SRA study SRP569925. Searching any of these in the dataset finder brings you back here.

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