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Impact of RORgt in regulating CD4 T cells primed under Th17 conditions

GSE291839 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/26 Platform GPL34290
Summary
CD4 T cells are an essential component of antiviral adaptive immune cell responses. Central to the functional capabilities of CD4 T Cells is their ability to differentiate into distinct subsets. Subset differentiation and maintenance is dependent on the coordinated and sequential activation of certain master regulator transcription factors. While antiviral responses are predominantly Th1, prior studies have shown that both T-bet and Eomes, two critical regulators of Th1 responses are dispensable for CD4 T cell mediated protection. CD4 T Cells lacking both T-bet and Eomes produce strong and highly protective Th17 response characterized by high expression of the transcription factor RORγt. Here we determine the impact of RORγt regulation in CD4 T Cells primed under Th17 conditions and also deficient in T-bet and Eomes. Our studies reveal RORγt regulates several hundred genes that in Th17 CD4 T Cells, thus providing a potential molecular framework for targeting protective anti-viral immunity.
Published in
T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors
Dhume K, Finn CM, Baffoe E et al. · Mucosal immunology 2025 · PMID 40819821 · doi:10.1016/j.mucimm.2025.08.005
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Also filed as BioProject PRJNA1235610 and SRA study SRP570162. Searching any of these in the dataset finder brings you back here.

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