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LSECs promote MASH progression via IL-1R1-mediated chemokine production induced by macrophage-derived IL-1β

GSE291866 Mus musculus Expression profiling by high throughput sequencing 3 samples Submitted 2026/01/31 Platform GPL28457
Summary
In LSEC of MASH model mice, Il1r1 gene expression was elevated, and CXCL10 gene expression was upregulated compared to the normal diet group. Macrophage-derived IL-1β, whose secretion was enhanced via autophagy impairment induced by fatty acid overload, activated JNK in LSEC, leading to increased expression of CXCL10 and CCL2. The expression levels of these chemokines positively correlated with the NAFLD activity score in MASH patients. Furthermore, spatial transcriptomic analysis of liver tissue from MASH patients revealed high expression of IL1R1, CXCL10, and CCL2 in periportal LSEC, which were in close proximity to numerous macrophages.
Published in
Liver Sinusoidal Endothelial Cells Promote Metabolic Dysfunction-associated Steatohepatitis Progression via Interleukin-1R1-mediated Chemokine Production Induced by Macrophage-derived Interleukin-1β
Fukumoto K, Hikita H, Saito Y et al. · Cellular and molecular gastroenterology and hepatology 2026 · PMID 41344438 · doi:10.1016/j.jcmgh.2025.101698
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Also filed as BioProject PRJNA1235686 and SRA study SRP570243. Searching any of these in the dataset finder brings you back here.

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