High throughput RNA-seq analysis in human primary chondrocytes treated with cyproheptadine and IL-1β
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 5 × Human primary chodroctes treated with DMSO (Control) vs 5 × Human primary chodroctes treated with cyproheptadine vs 5 × Human primary chodroctes treated with IL-1β vs 5 × Human primary chodroctes treated with cyproheptadine + IL-1βGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Histamine H1 receptor inverse agonists improve structure and pain in an osteoarthritis mouse modelThe Journal of clinical investigation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291878_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1235709 and SRA study SRP570259. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8843773 Human primary chodroctes treated with DMSO (Control) 1 Human primary chodrocte…
- GSM8843774 Human primary chodroctes treated with DMSO (Control) 2 Human primary chodrocte…
- GSM8843775 Human primary chodroctes treated with DMSO (Control) 3 Human primary chodrocte…
- GSM8843776 Human primary chodroctes treated with DMSO (Control) 4 Human primary chodrocte…
- GSM8843777 Human primary chodroctes treated with DMSO (Control) 5 Human primary chodrocte…
- GSM8843778 Human primary chodroctes treated with cyproheptadine 1 Human primary chodrocte…
- GSM8843779 Human primary chodroctes treated with cyproheptadine 2 Human primary chodrocte…
- GSM8843780 Human primary chodroctes treated with cyproheptadine 3 Human primary chodrocte…
- GSM8843781 Human primary chodroctes treated with cyproheptadine 4 Human primary chodrocte…
- GSM8843782 Human primary chodroctes treated with cyproheptadine 5 Human primary chodrocte…
- GSM8843783 Human primary chodroctes treated with IL-1β 1 Human primary chodrocte…
- GSM8843784 Human primary chodroctes treated with IL-1β 2 Human primary chodrocte…
- GSM8843785 Human primary chodroctes treated with IL-1β 3 Human primary chodrocte…
- GSM8843786 Human primary chodroctes treated with IL-1β 4 Human primary chodrocte…
- GSM8843787 Human primary chodroctes treated with IL-1β 5 Human primary chodrocte…
- GSM8843788 Human primary chodroctes treated with cyproheptadine + IL-1β 1 Human primary chodrocte…
- GSM8843789 Human primary chodroctes treated with cyproheptadine + IL-1β 2 Human primary chodrocte…
- GSM8843790 Human primary chodroctes treated with cyproheptadine + IL-1β 3 Human primary chodrocte…
- GSM8843791 Human primary chodroctes treated with cyproheptadine + IL-1β 4 Human primary chodrocte…
- GSM8843792 Human primary chodroctes treated with cyproheptadine + IL-1β 5 Human primary chodrocte…
- GSE205154 Bulk RNA-Seq gene expression data for 289 primary and metastatic pancreatic ductal adenocarcinoma (PDAC) tumor samples from FFPE blocks. 289 samples shares rna-seq, primary
- GSE297742 Bulk RNA-seq of primary tumor biopsy samples from prostate adenocarcinoma patients 234 samples shares rna-seq, primary
- GSE327289 Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary Tauopathies 76 samples shares rna-seq, primary
- GSE274335 RNA-Seq analysis LPCAT3 knockdown effect on primary human endometrial stromal cells(HESC). 6 samples shares rna-seq, primary
- GSE294300 Single-cell gene expression profiles of cells from primary colorectal cancer and adjacent normal tissue [scRNA-Seq] 36 samples shares rna-seq, primary
- GSE339484 RNA-seq profiling of 14 paired primary and recurrent glioma cases 28 samples shares rna-seq, primary
- GSE296117 A single-cell RNA-seq dataset of synovial fluid from rheumatoid arthritis treated with TNF-α/JAK inhibitor 18 samples shares rna-seq, treated
- GSE272346 Late-stage tertiary lymphoid structures in hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade [bulk RNA-seq] 14 samples shares rna-seq, treated
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.