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Natriuretic Peptides Modulate Monocyte-Derived Langerhans Cell Differentiation and Promote a Migratory Phenotype

GSE291916 Homo sapiens (human) RNA-seq (gene expression) 14 samples Submitted 2025/05/30 Platform GPL18573
At a glance

RNA-seq (gene expression) · human · 14 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
14 samples: 4 × monocyte-derived Langerhans cells - CTRL - 20D vs 4 × monocyte-derived Langerhans cells - BNP - 20D vs 3 × monocyte-derived Langerhans cells - CTRL - 23D vs 3 × monocyte-derived Langerhans cells - BNP - 23DGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Natriuretic peptides modulate monocyte-derived Langerhans cell differentiation and promote a migratory phenotypeFrontiers in immunology · 2025
Summary (written by the submitters)
Introduction: The interaction between the nervous and immune systems is crucial for maintaining homeostasis and can influence disease progression in inflammatory skin diseases, such as atopic dermatitis (AD). Sensory neurons in the skin can secrete neuropeptides that modulate immune cell activity, including Langerhans cells (LCs), the primary antigen-presenting cells in the epidermis.
Read the full summary ↓
This study investigates the effects of neuropeptides on the differentiation of monocyte-derived LCs (moLCs), specifically the neuropeptides with the most profound effect, i.e. atrial- and B-type natriuretic peptides (ANP and BNP, respectively).
Published in
Natriuretic peptides modulate monocyte-derived Langerhans cell differentiation and promote a migratory phenotype
Horváth D, Pénzes Z, Molnár P et al. · Frontiers in immunology 2025 · PMID 40552299 · doi:10.3389/fimmu.2025.1593141
This dataset
Open GSE291916 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291916_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1235775 and SRA study SRP570330. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40552299) ↗
Study design
4 × monocyte-derived Langerhans cells - CTRL - 20D vs 4 × monocyte-derived Langerhans cells - BNP - 20D vs 3 × monocyte-derived Langerhans cells - CTRL - 23D vs 3 × monocyte-derived Langerhans cells - BNP - 23D

Supports a between-group comparison across 14 samples.

How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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