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2p Gain-Driven REL Overexpression Confers Resistance to BTK Inhibitors in Chronic Lymphocytic Leukemia

GSE292026 Homo sapiens Expression profiling by high throughput sequencing 5 samples Submitted 2025/12/29 Platform GPL24676
Summary
Gain of the short arm of chromosome 2 (2p) is a frequent chromosomal abnormality in advanced Chronic Lymphocytic Leukemia (CLL), but how it contributes to CLL pathogenesis and progression is still poorly understood. Using a multiparameter approach that combines scRNA sequencing, cellular biology on primary CLL cells and engineered cell lines, as well as clinical analyses, our data show that 2p gain leads to NF-kB activation through REL overexpression, thereby contributing to BTKi resistance.
Published in
REL overexpression and sustained NF-κB signaling associated with 2p gain induce resistance to BTK inhibitors in Chronic Lymphocytic Leukemia
Dehgane L, Mallet E, Brasseur C et al. · Leukemia 2026 · PMID 41366531 · doi:10.1038/s41375-025-02818-w
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Also filed as BioProject PRJNA1236339 and SRA study SRP570521. Searching any of these in the dataset finder brings you back here.

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