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Effects of methylphenidate ingestion in male mice on the brains of their grandchildren.

GSE292294 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/31 Platform GPL24247
Summary
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder widely observed from childhood to adulthood, with methylphenidate (MPH) used as the first-line treatment. Recent evidence suggests that the preconception paternal environment can affect offspring health, potentially extending to multiple generations. In our previous study, we reported that MPH administration to sires induced decreased anxiety-related behaviors and memory impairment in the F1 generation. To extend these findings and examine the range of transgenerational effects, this study investigated the impact of preconception male MPH exposure on brain gene expression in the F2 generation.
Published in
Paternal exposure to methylphenidate causes behavioral abnormalities in grandchildren
Nakano R, Ikeda R, Yamazaki Y et al. · The Journal of toxicological sciences 2025 · PMID 40887248 · doi:10.2131/jts.50.445
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Also filed as BioProject PRJNA1237840 and SRA study SRP571355. Searching any of these in the dataset finder brings you back here.

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