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RNA-seq of PgrCre/+Srfflox/flox and Srfflox/flox mouse uterus at gestation day 3.5

GSE292391 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/09/30 Platform GPL19057
Summary
Upon conditional ablation of Srf in the Pgr-expressing cells of the mouse uterus, PgrCre/+Srff/f (SrfKO) females were infertile, displaying uterine fibrosis and failure to decidualize or support embryo implantation. RNA-seq analysis demonstrated dramatic changes in gestation day 3.5 SrfKO uterine tissues including dysregulation of cytoskeletal remodeling and growth response genes in addition to strong induction of proinflammatory cytokine signaling. These data show that SRF is key for endometrial function and fertility through regulation of inflammatory homeostasis.
Published in
Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis
Marquardt RM, Grimm SA, Wu SP et al. · Proceedings of the National Academy of Sciences of the United States of America 2025 · PMID 41150713 · doi:10.1073/pnas.2510060122
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Also filed as BioProject PRJNA1238286 and SRA study SRP571597. Searching any of these in the dataset finder brings you back here.

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