RNA Sequencing of Kidney and Skeletal Muscle Samples from Young WT and Klotho KO Male Mice
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 6 × Kidney, WT, vs 6 × Kidney, Klotho KO, vs 6 × Skeletal muscle, WT, vs 6 × Skeletal muscle, Klotho KO,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Universal transcriptomic hallmarks of mammalian ageing and mortalityNature · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292843_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1241719 and SRA study SRP572929. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8866540 Kidney, WT, rep 1 Kidney, WT,
- GSM8866541 Kidney, WT, rep 2 Kidney, WT,
- GSM8866542 Kidney, WT, rep 3 Kidney, WT,
- GSM8866543 Kidney, WT, rep 4 Kidney, WT,
- GSM8866544 Kidney, WT, rep 5 Kidney, WT,
- GSM8866545 Kidney, WT, rep 6 Kidney, WT,
- GSM8866546 Kidney, Klotho KO, rep 1 Kidney, Klotho KO,
- GSM8866547 Kidney, Klotho KO, rep 2 Kidney, Klotho KO,
- GSM8866548 Kidney, Klotho KO, rep 3 Kidney, Klotho KO,
- GSM8866549 Kidney, Klotho KO, rep 4 Kidney, Klotho KO,
- GSM8866550 Kidney, Klotho KO, rep 5 Kidney, Klotho KO,
- GSM8866551 Kidney, Klotho KO, rep 6 Kidney, Klotho KO,
- GSM8866552 Skeletal muscle, WT, rep 1 Skeletal muscle, WT,
- GSM8866553 Skeletal muscle, WT, rep 2 Skeletal muscle, WT,
- GSM8866554 Skeletal muscle, WT, rep 3 Skeletal muscle, WT,
- GSM8866555 Skeletal muscle, WT, rep 4 Skeletal muscle, WT,
- GSM8866556 Skeletal muscle, WT, rep 5 Skeletal muscle, WT,
- GSM8866557 Skeletal muscle, WT, rep 6 Skeletal muscle, WT,
- GSM8866558 Skeletal muscle, Klotho KO, rep 1 Skeletal muscle, Klotho…
- GSM8866559 Skeletal muscle, Klotho KO, rep 2 Skeletal muscle, Klotho…
- GSM8866560 Skeletal muscle, Klotho KO, rep 3 Skeletal muscle, Klotho…
- GSM8866561 Skeletal muscle, Klotho KO, rep 4 Skeletal muscle, Klotho…
- GSM8866562 Skeletal muscle, Klotho KO, rep 5 Skeletal muscle, Klotho…
- GSM8866563 Skeletal muscle, Klotho KO, rep 6 Skeletal muscle, Klotho…
- GSE303183 The skeletal muscle of aged male mice exhibits a sustained growth regulatory transcriptional profile following prolonged glucocorticoid exposure compared to young males 24 samples shares skeletal, muscle, young, male
- GSE255246 Intrauterine hyperglycemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling 10 samples shares skeletal, muscle, male
- GSE267727 Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, heart, and skeletal muscle tissue from mice fed high-fat, high-sugar diet [heart] 482 samples shares skeletal, muscle
- GSE186648 Skeletal muscle mRNA expression in 25 mice with or without genetic defects of mitochondrial fatty acid oxidation (Acadl and Acadvl knockout) using RNA sequencing. 25 samples shares skeletal, muscle
- GSE267909 Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance (bulk RNA-Seq) 14 samples shares skeletal, muscle
- GSE267910 Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance (snRNA-Seq) 12 samples shares skeletal, muscle
- GSE253735 Loss of skeletal muscle Bmal1 +/- Exercise Training [Mouse liver, heart, inguinal white adipose and lung tissues 64 samples shares skeletal, muscle
- GSE266918 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [heart] 63 samples shares skeletal, muscle
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.