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Differential expression of transcriptional genes in paclitaxel-resistant mouse gastric adenocarcinoma cell lines

GSE293310 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/07 Platform GPL24247
Summary
Paclitaxel is commonly used as a second-line treatment for gastric cancer, but the mechanisms underlying paclitaxel resistance remain to be further investigated. To address this, we successfully established a mouse gastric adenocarcinoma cell line (MPC) from murine gastric adenocarcinoma organoids. Subsequently, a paclitaxel-resistant cell line (MPC-PTX) was generated through multi-cycle drug stimulation. This model provides a valuable tool for studying the mechanisms of paclitaxel resistance in gastric cancer.
Published in
Dasatinib demonstrates efficacy in organoid derived paclitaxel-resistant Trp53/Cdh1-deficient mouse gastric adenocarcinoma with peritoneal metastasis
Liu W, Li L, Guo L et al. · Cell regeneration (London, England) 2025 · PMID 40299206 · doi:10.1186/s13619-025-00232-2
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Also filed as BioProject PRJNA1243988 and SRA study SRP582248. Searching any of these in the dataset finder brings you back here.

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