GEO series
An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation (RNA-seq)
GSE293374
Mus musculus
Expression profiling by high throughput sequencing
44 samples
2025/05/21
GPL19057
Summary
An ill-defined laminin-rich three-dimensional (3D) extracellular matrix (ECM) is typically used for the generation of organoids, but little is known about its function. Here, using tunable and chemically defined 3D hydrogels, we systematically explored the role of the ECM during murine intestinal organoid development. Our results highlight the utility of chemically defined matrices for studying ECM biology in tissue engineering and pave the way for the replacement of animal-derived matrices in organoid culture.
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Paper (PMID 40680738) ↗
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