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Dynamic fibroblast-immune interactions shape recovery after brain injury [snRNASeq_Cxcl12]

GSE293682 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/06/30 Platform GPL24247
Summary
Fibroblasts and immune cells coordinate tissue regeneration and necessary scarring after injury. In the brain, fibroblasts are border-enriched cells whose dynamic molecular states and immune interactions after injury remain unclear. We used single nuclear RNA sequencing at 21 days post photothrombotic (PT) injury to test the role of fibroblast-derived CXCL12 in regulating local immunity after brain injury. We find that loss of fibroblast CXCL12 causes dysregulated immune tone with elevated IFNg signaling.
Published in
Dynamic fibroblast-immune interactions shape recovery after brain injury
Ewing-Crystal NA, Mroz NM, Larpthaveesarp A et al. · Nature 2025 · PMID 40903576 · doi:10.1038/s41586-025-09449-2
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Also filed as BioProject PRJNA1245690 and SRA study SRP576409. Searching any of these in the dataset finder brings you back here.

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