The Chromosome 19 miRNA Cluster Guards Trophoblasts Against Overacting Innate Immunity
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The Chromosome 19 miRNA cluster guards trophoblasts against overacting innate immunityCommunications biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293705_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1246076 and SRA study SRP576230. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 5 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8888884 BeWo cells WT, control-1 BeWo cells WT, control
- GSM8888885 BeWo cells WT, poly(I:C)-1 C)
- GSM8888886 BeWo cells dA11, control-1 BeWo cells dA11, control
- GSM8888887 BeWo cells dA11, poly(I:C)-1 C)
- GSM8888888 BeWo cells WT, control-2 BeWo cells WT, control
- GSM8888889 BeWo cells WT, control-3 BeWo cells WT, control
- GSM8888890 BeWo cells WT, poly(I:C)-2 C)
- GSM8888891 BeWo cells WT, poly(I:C)-3 C)
- GSM8888892 BeWo cells dA11, control-2 BeWo cells dA11, control
- GSM8888893 BeWo cells dA11, control-3 BeWo cells dA11, control
- GSM8888894 BeWo cells dA11, poly(I:C)-2 C)
- GSM8888895 BeWo cells dA11, poly(I:C)-3 C)
- GSM8888896 U2OS cells, WT, control-1 U2OS cells, WT, control
- GSM8888897 U2OS cells, WT, poly(I:C)-1 C)
- GSM8888898 U2OS cells, C19MC, control-1 U2OS cells, C19MC, cont…
- GSM8888899 U2OS cells, C19MC, poly(I:C)-1 C)
- GSM8888900 U2OS cells, WT, control-2 U2OS cells, WT, control
- GSM8888901 U2OS cells, WT, poly(I:C)-2 C)
- GSM8888902 U2OS cells, C19MC, control-2 U2OS cells, C19MC, cont…
- GSM8888903 U2OS cells, C19MC, poly(I:C)-2 C)
- GSE130955 Global skin gene expression profile of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive immunity profile 91 samples shares immunity, innate
- GSE328649 Lineage 2-Beijing Mycobacterium tuberculosis strains suppress BCG-trained innate immunity early after infection 39 samples shares immunity, innate
- GSE312942 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity [RNA-seq] 36 samples shares immunity, innate
- GSE291337 Hijacking innate immunity to enhance mRNA therapeutics 27 samples shares immunity, innate
- GSE313114 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity [RNA-Seq dose_response] 21 samples shares immunity, innate
- GSE281351 RNA sensing induced by chromosome missegregation augments anti-tumor immunity V 16 samples shares chromosome, immunity
- GSE281348 RNA sensing induced by chromosome missegregation augments anti-tumor immunity II 12 samples shares chromosome, immunity
- GSE324662 Suppression of antiviral innate immunity by the COX2-PGE2-PKA signaling axis by inhibiting the cytosolic mtDNA-dependent activation of STING 12 samples shares immunity, innate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.