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Single nucleus RNA-seq of subcortical white matter from lysophosphatidylcholine (LPC) and cuprizone toxicity mouse models

GSE293850 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/04/09 Platform GPL24247
Summary
We compared the transcriptional changes in the cells of the corpus callosum, focusing on the oligodendrocyte and microglia, between LPC and cuprizone mediate demyelination. We further compared the transcriptional phenotypes to human MS patient samples. We identified distinct disease-associated oligodendrocyte states with shared pathological changes to MS, and observed a common but altered remyelination state between the models. Microglia response to demyelination is highly conserved, but human MS-associated microglia exhibit significantly more heterogeneity than we found in the mouse models. (doi: https://doi.org/10.1101/2025.03.24.645058)
Published in
A comparative transcriptomic analysis of mouse demyelination models and multiple sclerosis lesions
Aboelnour EL, Vanoverbeke VR, Maupin EA et al. · Nature communications 2026 · PMID 42151131 · doi:10.1038/s41467-026-72383-y
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Also filed as BioProject PRJNA1246592 and SRA study SRP576525. Searching any of these in the dataset finder brings you back here.

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