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CD74⁺ Myeloid Cells across Brain Pathologies

GSE293921 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/01/22 Platform GPL21626
Summary
In this study, we conducted a comprehensive analysis of single-cell RNA sequencing data from immune cells isolated from the brain tissue of mouse models of Alzheimer’s disease (AD), multiple sclerosis (MS), and brain metastasis (BrM). Our findings reveal a shared transcriptional signature among CD74⁺ myeloid cells across these conditions, indicating a conserved inflammatory response that may be amenable to therapeutic targeting. These results highlight the role of CD74⁺ myeloid cells as a unifying component of the immune landscape in diverse neurological disorders and lay the groundwork for future investigations into targeted interventions aimed at mitigating these pathologies.
Published in
MIF-Induced CD74+ Microglia and Macrophages Promote Progression of Brain Metastasis and Are Clinically Relevant across Central Nervous System Disorders
Alvaro-Espinosa L, Marquez-Galera A, Priego N et al. · Cancer research 2026 · PMID 41874311 · doi:10.1158/0008-5472.CAN-25-4018
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Also filed as BioProject PRJNA1247434 and SRA study SRP577042. Searching any of these in the dataset finder brings you back here.

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